When I started loading for the 250-3000 in the late 1960s, Winchester offered a pointed soft point 87 grain bullet and a 100 grain Silvertip, the same bullets that they loaded in their 257 Roberts ammo. I shot 'chucks with the 87 grain factory load and whitetails with the 100 grain Silvertip and both the Remington 100 grain PSP and RNCL factory loads. The 250-3000 rifles that I had at that time were a 99G with a Lyman receiver sight and a pre-WW2 99R that had been fitted with a G&H side-mount and a Lyman Alaskan. Neither were precision varmint rifles, but served the purpose as walking varmint rifles. Dairy farming was on the decline in northern New England and since pastures were no longer being grazed, they were growing up into prime 'chuck habitat.
I reloaded 75 grain Sierras in the 25-35, 250-3000, and 257 Roberts for shooting 'chucks thru the mid-1970s. I currently have 1 varmint rifle in 250-3000, a Ruger 77 with a heavy/varmint contour Douglas barrel. I haven't shot it for several years, but have nearly 100 rounds loaded for it with 75 grain Sierras over 38.0 grains of IMR 4895 and around 70 rounds loaded with 90 grain Sierra over 36.8 grains of IMR 4895. These loads were worked up back in 1993, shortly after I traded a Savage 99E for this Ruger 77. I'm sure that there are better powders now than there were 30 years ago, but since I never use this rifle and seldom even think about it, I haven't bothered to work up any new loads for it.
If I was going to build a new varmint load for the 250-3000, I'd probably start with the 75 grain VMax over Varget.
