I think I am done with load development for my three big bore handguns:

Freedom Arms .454 Casull, custom 10" octagon MagNaPorted barrel, with handloads of 240 gr. XTP Mags, 260 gr. FA JFP, 265 Swift A-Frames, 300 gr. FA JFP bullets.

Magnum Research BFR, .475 Linebaugh, 410 gr. Cast Performance bullets, at 1250 fps- handgun weight and grip make this load very manageable. Plans for taking this one back to Africa for large plains game- wife not crazy about taking on a Cape Buffalo, still working on it. In the meantime, back to TX for a Scimitar horned Oryx this fall.

Ruger Super Blackhawk, .480 Ruger, 410 gr. Cast Performance bullets. This is my off-road carry gun.

All three are very accurate, having taken game so far including coyotes, whitetails, red deer, hogs, and bison. The FA and BFR both wear Ultradot Gen 2 sights, 1" on the Casull, 30mm on the BFR.

Big-bore handguns are a serious affliction, making rifle looneyism seem like something sane, for me at least.
[Linked Image from i.imgur.com]

I'd rather be a free man in my grave, than living as a puppet or a slave....