I've got an antique 8bore and 12bore paradox rifle. I know of an 2" firearm and actually have some bullets from it. Some say that all bullets do the same thing, basically blood loss or if a lung shot its oxygen starvation to the brain followed by loss of blood pressure.

The question is when or what's the point whereball that business is no longer valid and pure mass and ft lbs energy of brute force take over