Please don't take this wrong, Steve. I'm not questioning the sense of this project.
Why? What was the impetus for it? What need does this fill?
Let me take a stab at answering this from my perspective. 6X45 would allow you to hunt deer with a 223-ish rig in a state that does not allow 223 REM as a legal round. My home ground, Kentucky, allows 223 REM already.