As others have stated, all three very versatile and capable killers. I don't think the game targeted could tell the difference in which one they got hit with as long as the proper bullet is used with good shot placement.

That being said I am currently shooting a 270. I sold my 30-06 several years ago. and I sold my 280Ai last year. I quit reloading several years ago and 280/280AI ammo is tough to find off the shelf in my neck of the woods.

My 270 is very accurate with factory ammo and it fits me well. Ammo is available everywhere. Its very comfortable to shoot and its a killer. that's why my pick is the 270 right now.

I do have an itch for a light weight 30-06 lately. And ammo is everywhere for that too. That might be my next pick soon if I find the right one, or it finds me.