I'd pick a 160gr NP at 2900fps for a general 280 Rem hunting load any day of the week. Would handle the bigger species of NA big game when the opportunity comes.

My 280 Rem MR was for sale on the second hand rack in a shop in SW Wisconsin. A good friend picked it up, but never used it, so he sold it to me. I quickly found out why it went down the road. 2 to 2-1/2" 100 yd groups were the norm with 140gr bullets. Brand made no difference. I ordered up a Score-High stock bedding kit from Midway, adjusted the trigger and Dyna-tek'd the barrel and accuracy is now where it should be. Looking forward to using it for a Western Kansas deer rifle perhaps on my uncle's farm. The 280 Rem is great on the plains.