I hunted with 300WBY for along time and liked it alot. Killed lots of stuff with it. Came upon a great deal on a Winchester model 70 classic in 300RUM and gave it a try. The rifle has been very deadly and on Elk, Black Bear, Kudu, Eland, Zebra and lots of other stuff over the past three years and I have been very impressed. I use a 180TSX at about 3350 fps. BUT...... the danged thing is LOUD! And, I am not at all sure the extra 100-150fps is worth the noise. I have been contemplating re-barreling it to 300WBY.
30grs less powder per load, less noise and I am thinking that a 180TSX at 3200fps will, as we say, git 'er done. As a current 300RUM user and lover, I say go 300WBY. If you need more than that, you need a 340 or a 375 of some persuasion. (I have those, too
)