Yep......all my current big game cartridges use either RL22 or RL25, sans my 'ole '06 using IMR4350.

When one finds a good powder that fits their criteria, buy bunches of it, more importantly, buy it in quantity in the same lot#. That takes care of the variation part.

Make sure that when you buy a can of any powder that there are plenty more available left to buy in that same lot# after your testing is completed. Makes very little sense to do otherwise.

After doing so myself, I bought six 5 pounders of RL22 and four 5 pounders of RL25 in the same lot#'s. My PDog/gopher .223 load using H335 is "the" load for my particular varmint rifles. 100 pounds of H335 with the same lot# ensures that it will remain so.

Uniformity in components and how we proceed through the entire reloading process can only help us to achieve more consistent results downrange.