An '06 can make a mess of a deer with a bad hit or an explosive bullet that is for sure. If you like to avoid meat loss both of the suggestions seem to help us.
The load it down to a 300 Savage [my brother in laws approach]using a 150 Hornady and around 44 gr of I4064 is a sweety.
I use a harder , heavier bullet than usually recommended for deer [i.e. 180 grain Core Lokts/Noslers]. It doesn't work quite as well but I don't rezero for elk.
I finally quit using 165 grain boattails on deer due to what I feel is excessive amounts of bloodshot meat, etc.
