Just returned from a Wyoming mule deer hunt yesterday, I took a nice fork horn buck at 66 yds with my Ruger 41 Bisley. From my 5 1/2" barrel I get 1325 fps using a 230 gr Keith & 18 grs of 2400, standard primer, mixed brass. The buck was facing me straight on & the shot hit him just left of center, nicked the shoulder, went through one lung & the top of the heart, exited the diaphram into the guts & exited in front of the right hind quarter, he was alive 4-5 seconds & ran maybe 50 yds. My alloy is straight wheel weights. This combo works great & we've used it up to bull moose size with one shot kills.
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Dick