I shoot a Redhawk in .44 mag. My handloads are designed for accuracy and hunting. I can keep them all in a kill zone for deer out to 75 yds with open sights. At 50 yds, I can hit a soda can 6 out of 6. That said, my brother shoots a SBH. He can shoot his as accurate as mine. However, in bear country, I like the comfort of DA. That quick second shot may save a life(mine).
In a ransom rest, you may see some accuracy differences, but with the human factor thrown in, not sure you could see a difference.
