7828 and H1000 are PERFECT POWDERS for the 300 wby. Some remingtons don't have the free bore that wby rifles do and can get to max pressure alot quicker. If you had a normal wby I'd say you should work towards 85/7828 under a 180 and 87/h1000 under the same BUT WITH THAT REMINGTON you may hit max at about 4 grains under these loads. Work up carefully with a chrono. Also strongly consider the newer super bullets by nosler in the e=tip and barnes with the tsx. 150-165 grain solid copper bullets like these will do anything that the older cup and core 180's used to do.