What I have found in 45 years of reloading is that each rifle has it's own preferences. My wife's 22-250 likes IMR4064 and mine prefers H4895. If you have have some medium burning speed powders on your shelf try them first. Most 22-250's are easy to please.
Doc

"No free man shall ever be debarred the use of arms. The strongest reason for the people to retain the right to keep and bear arms is, as a last resort, to protect themselves against tyranny in government." Thomas Jefferson, 1776