In thinking on this all my hunting needs have been served the past 20+ years or so by 3 cartridges,though I do play and hunt with others from time to time.....
270 Winchester
7 Rem Mag
375 H&H
One of lifes tougher chores is choosing between the 30/06, the 7RM, and the 270 Winchester.Luckily I don't have to so don't bother worrying about it until time to go hunting