My .44 Mg is a 4 5/8" SBH and im far from a huge handgun hunter but have shot a few deer, and elk and a bear with it from 25-60yds. I run my 240gr XTP's over 24.5gr of H110 and have yet to have one stay in an animal of any sort.

Of course my home poured (wheel weights) 245gr LSWC's over 20.5gr of 2400 havent stopped in an animal either.

curious to try the 300gr loads but have several hundred of each above bullet to use up first