Experience Here:

Pretty much what Greydog says!

The ammo will also have to be tuned correctly via reloading for that rifle and action. And some single shot actions/rifles do amazingly well with select (lots) factory ammo these days.

Think harmonics and best fit ammo for a particular breech and action.

Expectations for the tune:

1 moa almost always possible.

.500 achievable, and consistent, depending on tune, action,
ammo selection/or reloading.

.300 and .200 will happen, but not consistently possible even from bench.

Single shots will hunt, and you might occasionally win/place in a match outdoors w/wind. Think best of the best e.g.: action harmonics, shooter, wind-doping.

Just my 2 cents worth, and remember single shots are always going to be slower under duress than a bolt action repeater when something can claw, bite, grind you to dust, or tear you apart, frown !