I am thinking about a new left-handed 22lr bolt action. I was thinking about the CZ 452 American or LUX.
If you're going to go with a new, left handed 452 then jump on it as they have been discontinued and replaced by the 455. I'm sure some dealers still have them hanging around.
I just picked up a 455 as a back-up/guest rifle for silhouette shooting. I haven't had a chance to get it the range to see what it likes yet (hoping cheap!). The trigger was 5.5 lbs out of the box and my smith reduced to about three.