DaveH: See my previous post regarding keeping the Skunks from spraying at the shot.
I have not tried the 22 sub-sonic loads on Skunks to date but I have several friends who use these loads on feral cats and similar sized semi-urban Varmints.
I will ask them how the sub-sonics work on Skunks and if any of them have tried these out.
Good luck - I know what an obnoxious and offensive situation they can create.
Hold into the wind
VarmintGuy