It's more about accuracy in what load you should choose. Then I look at downrange performance.
I shoot:
180 gr in 300 win mag.
165 gr in .30-06
150 gr in .308
130 gr in .270
As somebody else pointed out, each caliber has a sweet spot. Why screw with it. Any of the above will smoke a deer and won't explode on impact from being driven at warp speed.
A man after my own heart
. Don't leave out the 200 gr in the 300 though. Oops, forgot we're talking deer here. The 200 puts the elk down in a hurry. Who uses the 300 on poor old deer anyway
. I've actually used the 165's in the 300 winnny with good luck. The 180 is probably the better bullet though if your using the oldstyle bullets and worry about bloodshot meat.