"The larger frontal area and the most momentum will always trump light and fast."

Yes, that is what my question was about. I have always wondered how more frontal area would compare to small frontal area at the same FPE.

My opinion is that the larger bullet hole and larger frontal area would come out ahead, but I have no proof of that.

John Taylor with his formula for knock out put a lot of emphasis on frontal area. Although he was talking solid bullets and head shots on elephant, I think the same principal would apply if the bullet was aimed at vital organs, too.

Those old .50 caliber buffolo rifles did not have a lot of FPE, when compared to modern cartridges, but, from what I have read, they were adequate for the purpose.