I've had great luck with almost any 50gr bullet and 19.5grs of IMR4198. I've tinkered with many other powders, but never bested the results of 4198. I don't try to make the little Deuce into something that it's not, and just enjoy the mild report and exceptional accuracy.
+1...
and not that i've seen too many sorry loads with any combo, but for me, 4198 is the powder...
my loads are averaging 19.1 gr... and that is because i made a powder scoop to load them with and that's what it holds when scooped and struck off with a business card...
most of my bullets are the sierra 50 gr spt....