I don't use H4350 but know it is an extreme powder which is advertised to be temperature insensitive.
I do use H414 and know it to be very sensitive to temperature. Not only will your POI height vary significantly with a 20�F temperature change, but accuracy will also suffer.
I use 180gr bullets with H4831, (an extreme powder,) and my hot load, (which isn't very hot really,) gets about 2600fps. I know H4831 to be temperature insensitive with a change in POI less than 3" with a 70�F temperature swing. Accuracy was not affected.
Varget works well with 150-168gr, also an extreme powder.
I'm doing a ladder test with H4895 with some 150gr FMJ for my US Model of 1917 Eddystone, with good results so far. I think I'll have a load traveling at 2960fps, a little less with the cold-bore.