Congrat, Eric. I've been totingsaw along a Redhawk just yours for years in hopes of shooting a deer with it, hasn't happened yet though. I usually load a Remington 240gr SJHP over 24grs H110.
The only animal I ever shot with the 300 gr XTP was an average blackie that I killed with a frontal Kennedy shot, worked very well. Maybe a bit too well actually.
I was using a rifle, and impact velocity was right around 1,500 fps.
I haven't tried the Hornady flex tip you asked about. Seems like I remember something about some special case prep required due to the length of that bullet. I'll check my Hornady manual when I get a chance and confirm this (or not).