204 upside:
-Less powder
-Less recoil
-Less muzzleblast
-Better external ballistics downrange than the 22-250 (generally speaking. Ppl like to argue this but the numbers don't lie)
-Can be loaded with trailboss to mimic 5mm rimfire performance with ZERO recoil and low noise

22-250:
-meets a .223 requirement some states have, if you plan on hunting deer
-If you go up to a 1-9 or 1-8 twist shoots heavier bullets that can do things the .204 can't

I am a huge .204 fan and more often than not a pair of my .204's come with me and my 22-250 stays in the safe when I head out of the house.

--Duck911

The DIPCHIT ADD, after a morning of drinking:

You despair, repeatedly, constantly! daily basis?
A despair ninny.
Sack up, despire ninny.