I've got three CZ 527s, a Hornet, a Fireball, and a .204. A .222 and .223 would finish the crew nicely, but I get along just fine with these three. Then again, the biggest varmints around here are coyotes, and they are few on the ground, locally.
The .204 has worked well for me, though, using 32gr. Ballistic Tips, decisive would be the operative word here.

You can roll a turd in peanuts, dip it in chocolate, and it still ain't no damn Baby Ruth.