This was a factory loaded 450 Hornady 350 FN load. It was recovered from a piece of the belly skin on a 15 foot whale (beluga). The bullet was fired from about 5 feet above, through the back, downward. A second bullet disintegrated in destroying the skull.
This 300 Speer Uni-Cor punched through both shoulders (scapula) of a bull moose. I used a 45-70.