I've had much better luck anchoring coyotes with a .243 than with a .223 or even a .22-250. The .243 isn't fur friendly, but if you just want coyotes dead, it's more effective than the lighter calibers. I went through .17s, .223s, .22-250, and even a .308. When I tried a .243 I stopped looking for anything else. Nothing has killed more effectively, especially once the range gets long. A .22-250 with a .75 gr. Amax or something like that might come close, but then you need a faster than normal twist. Light .22 bullets shoot nice and flat out to 300 yards or so, at longer ranges they drop like they're falling off a table.
