My 1921 takedown would shoot sub-MOA with Rem CoreLokt, Sierra 100 flat base or Speer 100 flat base, over Reloder 15.
It shot the 117 Hornady RN to about 2.5 inches at 100 yards.
My present .250 is a late-forties EG. I haven`t shot it too much, but it groups the Speer 100, Hornady 100 or Hornady 87 into about 1.4 inches, and the 117 RN to about 3.5 inches.
The 117 load is one recommended to me by Mule Deer some time back; 41.5 grains H4831SC, and that powder is a tight fit!