I hunted South Africa this year for the first time. I took Red Hartebeest, 2 Blue Wildebeest, Gemsbok, Impala, Eland and Zebra all with a 30-06 shooting 168gr Barnes tipped triple shocks. My wife hunted for her very first time ever and took Blesbok, Red Hartebeest and Impala all with a 7mm08 and 139gr Hornady BTSP.
No problems on any of them. I thought a long while about taking my 375HH or my 9.3x62 but based on personal experience, others thoughts including JJHack and the 30-06 being my personal favorite cartridge, elected to take it.
I would do it again too.