Haven't taken but a dozen-odd 'big game' animals, but haven't lost one yet. One antelope I shot badly was a horrible thing, however. She was bedded down and I must have spooked her just as I squeezed, and the round unzipped her belly as she stood. UGLY. Ended up putting 3 more 7RM rounds in her as she ran along dragging 20 feet of intestines behind her. A bud with me finally rolled her with two .35 Whelen rounds. Not a proud moment, that.