for me its like this, you get one or 2 rounds less in the magazine, and the ammo is alot more expensive than 9mm. The other is as time has past the 357 sig seems to be loaded to less and less pressure and isn't as much of a difference over 9mm as it was originally conceived. I think its a very interesting little round, but for me I have moved all my semi autos to 9mm, they all take the same ammo and it cuts down on having odd ball stuff floating around that only gets shot in one gun. with all the other stuff I shoot, 22lr, 17hmr 9mm, and all the other centerfire rifles I shoot of various calibers I don't want or need another type of ammo to keep up with. although I may break from that as the new 17wsm looks really cool.