Interesting.... in my Ruger, I was shooting 27 grains under both a 35 grain NTX and a 40 grain Varmaggeddon bullet and didn't seem to phase it at all... neither in the Rem VLS...

may be the seating depth... or the primers used... but CCI and FEDERALS perform the same...

but Ackley338/06 makes the good point of working up as each rifle is an entity onto itself...