I have a Ruger Predator/.223, and it shoots the 65gr Sierras like a champ. I have used BL-C2, W748, and AA2460 so far, and used starting loads for each from the middle of the range recommended by the Sierra tech guys. No optimization attempted. They all shoot 2"-2.5" for five @ 300yds from a rest. these are not max loads by any means, and typically W748and BL-C2 turns in the best accuracy at or near the top end of the load range.

I bought one box to try 'em, and another 700 when I was done with the first trip to the range.

Experience is what you get,
When you don't get what you want ;-0