RL 25 and 33 do things that other powders can't quite match. 25 is a wonderful 300 H&H/WinMag/Weatherby powder in a correct barrel (26" minimum) and 33 works very well in the big 338s.
As several have pointed out, the barrel means a lot. There is a world of difference between a conventional 4 groove 24/26" and a Nitride treated 30/36" 3 groove.
A 245 gr 338 Bore Tech bullet easily exceeds 3000 fps in a 338 Lapua or RUM carrying a state of the art long barrel and shoots flatter to 1000 or more than any 300 gr Berger alternative. BT BC is .869 Berger is .818.
RL 33, Retumbo or H 869 will do it.
Not "hunting rifles" but still lighter than a Barrett.