Yeah, I have no doubts the 320 Woodleigh would do fine. As I recall at least part of the reason for that particular Woodleigh is shooting water buffalo in the Northern Territories of Oz, and water buffalo are even bigger than Cape buffalo.
The 286 Nosler Partition is one of the newer models with the partition moved forward. It penetrates VERY deeply, like many of the other heavier Partitions, including the 250 .338 and 400 .416.
