We have used Interlock handloads and factory ammo in .260, 7mm-08, 7x57, 25-06, .270 Weatherby Mag, and 30-06. The only deer we have had to track an excessive distance was a 120 lb-ish doe hit center of the lungs behind the shoulder with a 129gr from the .260 from 50 yards. Bullet missed bone and heart and the deer went probably 150 yards but I consider that an anomaly. Hit in thick timber late PM and had to go back the following morning because of a very scant blood trail. But a couple of years later I hit same sized doe in same spot and it was a DRT with hardly a quiver. With the 7mm-08 and 139gr IL I have seen lung tissue 10 feet behind the impacted deer.
What I'm getting at is if you hit a deer in the chest with a Hornady Interlock, at least in my experience, that deer will die close enough from the shot to be found. All bullets don't hit exactly where we thought sometimes.
