I've also had erratic results from Hornady round-noses, both the 160 6.5mm and 180 .30, as opposed to very reliable results from the Spire Points. Have seen the 160 6.5 at only 2200-2300 fps go through both shoulders of a deer and exit, and not reach the far ribs on a behind-the-shoulder shot on the same size of deer.
If somebody wants to use a 220 in a .30-06, obviously they want penetration. So why not use the 220 Nosler Partition? It expands easily even on light game (due to the softer front core), yet penetrates VERY deeply. In fact it's one of the deepest-penetrating .30 caliber bullets available.
I don't shoot 220's in the .30-06 much, but when I do have had excellent luck with 55 grains of H4831 (either "long" or short-cut) for about 2500 fps.
