The latest Lyman cast bullet handbook has loads for the 327 Federal.

I load the 115-grain bullets to just over 1,200 fps and I am happy with cast bullet performance in several 327's.
I like Hodgdon Lil' Gun and 11.2 grains behind the Lyman 311008 will give me 1,220 fps from the 4" barrel Ruger GP 141 (GP100).
The same load runs about 1,240 fps in the 5.5" Blackhawk and it is a good load. At 25 to 50 yards I like 1,200 to just shy of 1,300 fps for smaller critters and cast bullets.
10.3 grains of Alliant 2400 will push the 122-grain NEI #82 bullet 1,292 fps in the Ruger GP141 and 1,321 fps in 5.5" Blackhawk. The NEI #76 is a 125-grain SWCGC bullet and 10.3 grains of 2400 will push it 1,330 fps in the Blackhawk. I prefer 11.2 grains of Lil' Gun for 1,287 fps in the Blackhack.
Here is an old load thread from the Shooters forum.

http://www.shootersforum.com/handgun-cartridges/47667-327-federal-thread.html

I'll be honest, I don't know how to post high performance load data for heavy bullets on an open forum. The Blackhawk and the big Ruger GP141 will take some "barnstormer" loads.

Slim