I have used the 130gr Hornady IL a lot on deer, but haven't used them on anything else. However, I have a brother who has used them to take deer, elk, moose, caribou, all four of the North American sheep, and two grizzly bears. He has always used reloads I put together for him, 130gr Hornady IL, 55grs. of IMR4350 in Win. cases and Win. primers.