I ran a 280 Ackley for a while. Great cartridge. That being said I just finished a do all custom and went with the standard 280 remington.

I find the standard variety does everything the Ackley did, just a little slower but also with less fuss or cost.

There is nothing particularly magical about the Ackley. It won't kill anything deader than the 30-06 will. If you are a tinkerer then go for it. If not, don't. Just my opinion...