I popped a whitetail this year with a 80 grain TTSX at 3900 fps MV out of a .257 Weatherby. Since the range was only 68 yards it had most of it left. Anyway, I caught the back of the shoulder, blew a fist sized entrance hole and a bullet sized exit just behind the far shoulder. It still ran maybe 40-50 yards with a blood trail 8 feet wide. I don't know about you, but I'm getting sick of my stories with Barnes bullets ending with "And then it ran away and we looked for it". This one was a science project to see if hyper speed was going to drop animals better; I think its safe to say I'm going to go back to bullets with lead in them and leave the TSXs and TTSXs for buffalo and such.