Although your Ruger 77RL has a 1-10" ROT, I prefer to shoot lighter bullets in my 250-3000s due to their smaller case capacity. I like either the Hornady or Sierra 75 grain bullets for varmints and the 87 grain Hornady and Speer, HotCore and TNT, for an all around bullets. I have found that the 87 grain bullets will shoot to approximately the same POA, so I can shoot coyotes with the TNT and deer with HotCores without having to re-zero.
I don't think that I've owned a 77RL in 250-3000, but recall that the wife of one of my favorite gun sellers, the late Bill DeVeux of Norwich, VT, shot a 77RL in 250-3000. Bill shot a deluxe grade 722 in 257R that I lusted after when I was a kid.
