This thread is interesting and about to die because it is one of the very few, where everyone is right for their own use.
Being a "heavier" game cartridge, it offers flexibility from deer to big bears and with a flat trajectory familiar to most riflemen.
All bullets work, some perhaps a little better than others where a little more penetration is apt but in end, it is likely only the big bears that require any consideration at all.
I have always had a lot of .338 caliber bullets on the shelf and the .338 and .340 keep appearing in my rack. This and the .458's, and perhaps the 7x57 and maybe the .30/06 are the constants that always work. Guess that is why they are getting older and still delivering the goods.