My 3-15x50 with the Z800 has provided excellent service for a few rough country elk hunts on a 300 Weatherby that generates more than a little recoil and has been dragged through several miles of oak brush, sage, snow, rain etc. without a hiccup.
To my eyes the glass is nicer than the VX6 and it would be a good choice for any kind of hunting short of moonlight night hunting and even by moonlight it isn't terrible.
If you like Zeiss glass you will like the HD5 on your big gun. When I had a 375 H&H I put a Leupold 1.75-6x32 on it and regretted not going with a Conquest because it was not as fast and comfortable for me. It was a Remington Classic and I decided it wasn't going to be what I wanted for an Africa or Alaska gun and sold it.