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That 100 grain Hornady is all you will need for deer.

A bud used em for a few years on everything from varmint sized critters to deer. No issues at all.

It appears that Hornady has discontinued the 100 grain bullets in .257. That was my preferred bullet for the last 25 years. That bullet at 3350 fps put the deer down right there. I am on my last box of the 100 grain flat base bullets. I will probably just move up to the 117 grain soft points. They are not quite as accurate as the 100s, but they still work great.

Man this thread just hit me hard. I just realized I bought a Ruger No.1 in .25-06 last July and STILL haven't shot it. That's never happened to me before. (I own a couple family heirloom guns I've never shot, but I've never bought one and not shot it right away)

Part of it was not wanting to get deeper in debt rushing to get what I needed to shoot it. The other was just not being able to get the stuff. But I've had a the scope mounted for many months. Had dies, brass, bullets and the last hold up, powder for over a month now. So sad.

100 grain Partition should replace the Hornady rather nicely.

My rifle thrives on 4350 and the 110gr Accubond.

The 100gr Hornady ammo will do just fine on deer. I've got a Kimber in 25-06 and it will shoot anything between 90 and 120gr. Preferred powders are R22 and 4831. I'm currently shooting Berger 115gr bullets for deer, know my chances of getting an exit are slim but most of my shots are under 100 yards and when I do my part they're on the ground inside of 50 yards. Careful letting your 12y/o get their hands on it, you might not get it back.

I have a .250 Savage barreled T/C pro hunter...the only rifle I carry anymore. I shoot 117 gr SST bullets out of it with deadly results.

I also have a 25-06 pro hunter my son uses shooting the Hornady 100 gr interlock. Two years ago he dropped two does with the Hornady 100 g bullets at over two fifty hundred yards with complete pass throughs. Last year he shot a 4 point at 80 yards with no bullet exit and couldn't find the 100 gr bullet. The little buck was dead right there. Load is 51.0 of H-4350 @3389 FPS.

My favorite bullet for the 25-06 is the discontinued Hornady 120 gr. hollow point. I'd hunt Elk with that bullet in a nano-second.

I had a couple 25-06’s. One was the Police/Tactical model, it shot really well with anything. I liked the 75 grain Vmax for yotes. 117’s for deer.

I guess I have shot the .25-06 when it was still a wildcat.. My current one is about 1000 rounds old and very accurate... I have used 115 BTBT, have some partitions loaded in that wt.. but never used them.. It would be used more if I did not have other rifles.. For many years the .22-250, .25-06, and .300wm were my three rifles for my hunting... I still have all three.. For the .25-06 around 52-53 gr. of I4350 has always been very accurate.. I usually used 100 gr. Horn. BTBT, or Sierra.. I like the 100 gr. because I can get it to between 3350 and 3400fps.. That makes hitting deer or coyotes much easier of shots that require fast action.. Sierra told me years ago I4831 was the powder of choice.. I bought a bunch of it and it has been my choice since then.. Many of the newer powders mentioned are also excellent I am sure, but just have never used them.. Good luck and enjoy..

I still have my first .25-06, a pre-war Model 70 that was rebarreled in 1965. I've had four other .25-06s and never found a better powder than H4831. My favorite bullet for a long time has been the Sierra 117 ProHunter. I think that bullet was discontinued a couple of years ago but the GameKing may shoot almost as well.

They did discontinue it, which makes me sick. I have no idea why H thought that was a good decision.

I picked up several hundred before they disappeared for good.

My second pick is the Nosler 100 gr BT. Those will get loaded once the IL’s are gone.

That 120 grain Hornady is my preferred choice, unfortunately my remaining supply is getting low. Performance is amazing

One caution with the shorter bullets. They do not buck the wind as well. I traded my .25-06 Model 70A for a 7 Mag after killing an antelope with a neck shot at 383 paces when I was aiming at the heart. The wind blew that 100 gr. Hornady Spirepoint all over the place. I was just lucky it flew into a killing zone. The 140 gr 7mm does a lot better job of staying straight, in my experience since then. Also, I respect the wind a lot more and pass on the shot if it is too erratic. Maybe that is the real secret.

Yeah I can vouch for that as well.

Shot a doe antelope at about 300. Wind was barely noticeable but it drifted back into the guts.

Doe ran out into the middle of a big sage flat and just stood there. No way to get closer without spooking her off.

She must have been late cycle because three bucks were circling her and trying to mount her hunched up form.

Poor girl finally died after an hour and a half.

I just ran a couple of calcs with the Hornady calculator. I compared the 100 grain spire point and 139 grain spire point, both launched at 3300 fps. With a 10 mph wind there was about 1.5" difference in wind drift at 400 yards.

Not really an issue where we hunt, longest shot we will typically take is 200 yards.

Speer 100g HOT CORES are an excellent bullet, 120g also if you can find any.

I originally used H870 with 117gr and 120gr bullets. Very consistent, but H870 is long discontinued. In about 1991, I switched to RL22 and have not looked back.

It’ll kill the hell outta medium size game

As many have mentioned 100gr pills will work great for your application. I prefer the 100 NBT and RL19 for a general purpose load. Right around 3,300fps depending on the rifle. I used Nosler Data for my powder charge and found it to be spot on for my current 3 and the 2 I foolishly let go. Have a Stash of the 120NP's that are OLD, the lathe marks on the jackets are pretty cool and they seem to retain as much or a tad more then the new 25 cal NPs do. No proof however. YMMV but I think loading some at around 3,000FPS should be a hoot for him to shoot at the range and in the field.