Personally I'd say .450 NE
I've got one. Ruger made 250 of them in 450 Nitro Express. At 7.5 pounds, it's really too light.....recoil is beyond fierce firing 500gr bullets at 2414fps or even 300 grainers at 3050fps.
I was curious about that one. I opted for the 450/400 version of the same rifle and that works very well.
The 450NE is supposed to fire 480 grains at 2150fps, NOT 2414!! Did you intend to say that or is that an error? That is a big step up in power and pretty irrelevant to a review of the gun in question.