Don,
I have been shooting cast in the Hornet and Bee with varying results for quite some time. .22 caliber cast bullets will make you talk to yourself in a rude manner. I have about broken the code though (with help from others) and I may be able to save you a little time.
I cast my own bullets and have found the NEI #1 39 grain and the Lyman 225415 48 grain bullets give the best results in my Marlin 1894CL.
I shoot both bullets as cast, with and without gas checks. I lube them with Javalina Alox or tumble lube them with Lee liquid Alox. I can detect no difference between lube methods for low velocity loads.
I believe that Western Bullet Company used to sell .22 caliber cast bullets. they are not listed now but here is a link to them;
http://missoula.bigsky.net/western/Lyman .22 caliber gas checks work fine for me. With low velocity loads I have been achieving the same result without a gas check.
You did not mention what type of rifle you are using?
Here a few low velocity loads that have worked for me.
Lyman 225415 using Winchester brass and Winchester small rifle primers. I seat these to the crimp groove and just straighten the case. I have not had a problem with the bullets being pushed into the case by the magazine spring.
Accurate Arms No.2 2.5 gr. 1231 fps, 3.0 gr. gives 1351 fps, 3.5 gr. gives 1467 fps, 4.0 gr. gives 1578 fps.
These loads (except the 4.0 gr. load) give head shooting accuracy for cottontail rabbits at 50 yards. Beyond that bullet drop comes into play and certain hits are difficult.
Do not start off with Alliant Unique, 2400 or either of the 4227 powders. These powders will give good accuracy with reduced loads but the loading technique is more difficult and they are position sensitive. A.A. No. 2 is also position sensitive but to a lesser degree.
Here is a link to Greg Mushial's web site;
http://www.gmdr.com/Greg has turned my thinking around on fast powders for light loads. I am currently shooting Hodgdon Titewad and Alliant Bullseye in the .30-30 and the .30-30 Improved with superior results. These powders show no tendency toward position problems. Read Greg's forward carefully before starting.
Keep us posted on your results. If you insist we can discuss 4227, 4198, Unique and 800X, but you are better off starting with more modern, less position sensitive powders.