One seems to be replacing the other.....
The main difference is the construction and speer dropping other proven bullets for the new design.
Speer is using there gold dot/uni-core knowledge of there pistol bullet line and incorporating it into rifle bullet lines.
I like the new bullet, but the bastards got rid of some good standby hot core bullets in the "this is better" move. I have used hot cores for years in various calibers and trust them completely. The 7mm 160 speer spitzer WAS a hell of an accurate, affordable and very deadly bullet for my .280, but it seems to be extinct now.....
Full curl bullets follow the same "gimmic' as the gold dot/uni-core/fusion bullets. The gold dot/uni-core/fusions I have shot from my .44 and a 7 mag perform well. Shooting very accurate and not yet having one come apart when shot at different bullet stopping mediums. I have killed no game with them yet, but my tests show the fusion/gold dot/uni-core/full curl are very tough, and expand very well. Hate to say it, terminal performance seems to be more consistent than the good ol' hot core.
I think we will see a day where speer will just have the one line of hunting bullet, chit canning there grand slam, mag-tip and hot-core altogether. I believe the full curl is the step in that one bullet direction.....