If you're really serious about using a .22 caliber rimfire cartridge, then I'd recommend a super-accurate heavy-barreled bolt-action, clip-feed .22 rimfire rifle like a CZ453 "Varmint" (heavy barreled, adjustable single-set trigger) rifle and use super-accurate "match" ammunition in it like Tenet or Wolf Match Target.
With such ammo, you need not be concerned about "flyers" since this ammo is very, very accurate, shot-after-shot. Thus, the concern about reloading is eliminated.
To further obtain greater accuracy, you could weigh and measure the the rims of each of the cartridges and group those with the same weight and rim thickness together for added shot-to-shot accuracy.
Target or "bench-rest" ammo is usually sub-sonic (around 1100 fps), so a .22 rimfire using such ammo doesn't make a lot of noise since the bullets come out slightly under the speed of sound. Yet, they are only about 100 fps slower than the so-called "high velocity" .22 rimfire cartridges.
Thus, there is no "crack" when fired since the bullet does NOT break the sound barrier and thus, there is no bullet-created "sonic boom" which is caused by the bullet exceeding the speed of sound (about 1125-1150 fps depending on your altitude).
If you're willing to PAY for absolute accuracy, then you might even consider an $1800 "Anschutz" (sp?) bench-rest rifle. Of course, it's too big for a "truck rifle"... and too expensive as well. But if you wish to "worship" at the cradle of accuracy, you need to have a rifle and ammo that will consistently get the job done.
That said, a pillar-bedded, free floating heavy-barreled CZ453 with a factory installed single-set trigger (for better accuracy) using Wolf Match Target ammo should get your job done with ease.
My own pillar-bedded "varmint" model (hvy. barrel) CZ453 will normally shoot all bullets into a quarter-(coin)-sized group at 50 yards consistently... and, if I do my job, sometimes it will "do" even a dime-sized 5-shot group at 50 yards from a solid rest. Only rarely will there be a "flyer" and it will still stay within an inch (or less) of the rest of the "group".
Such a rifle listed for $590, and will generally cost you $475-$525 retail with a discount if you can find a new-in-the-box CZ453. They have been replaced by the CZ455. I recently visited the CZ web-site and they are still offering the 453 model which indicates to me that they still have some new-in-the-box rifles.
However, even a used one that was well-cared for should get your job done as well. However, expect to pay for it since they aren't made anymore & the vast majority of their owners know what an excellent & very accurate rifle they are.
Strength & Honor...
Ron T.