I'm gonna have to say all of them. I guess I'm a bit like a butterfly flitting from flower to flower playing with whatever happens to strike my fancy. Currently my choice would be my Oberndorf Mauser custom chambered to the .35 Whelen. It was what I used on my last elk hunt and most likely will be used on my upcoming elk hunt. For deer and smaller game I like several that have always worked for me including an FN mauser (J.C. Higgins M50) in 30-06 that has been one hell of a lucky rifle. It was given to me by a late friend who couldn't use it anymore due to a serious shoulder injury. Currently is sits in a Butler Creek synthetic stock that I used to replace the original on the gun which got broken when I took a nasty fall. Funny thing is the rifle is a lot more accurate in the new stock than the rather fancy one that got broken. Another trustworthy rifle is Ruger RSI in .308. Ever der taken has been a one shot kill at ranges running from 6 feet to 250 yards.
Another rifle I may get to trust is a Winchester M70 Featherweight in 7x57. It's very accurate and it feed slicker'n snot on a doorknob but I've only hunted it once and bad luck and a ruined knee cost me the deer I shot with that rifle. If I draw a tag for deer this year I'll take it but the RSI will come along as back up.
My wife has only one rifle so it has to be her trustworthy gun. It too is a Ruger RSI in .308 and she shoots it well.
I really would have a very hard time picking out, "Just one."
Paul B.